Radiological and clinical predictors of scoliosis in patients with Chiari malformation type I and spinal cord syrinx from the Park-Reeves Syringomyelia Research Consortium.
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Strahle Jennifer M, Taiwo Rukayat, Averill Christine, Torner James, Shannon Chevis N, Bonfield Christopher M, Tuite Gerald F, Bethel-Anderson Tammy, Rutlin Jerrel, Brockmeyer Douglas L, Wellons John C, Leonard Jeffrey R, Mangano Francesco T, Johnston James M, Shah Manish N, Iskandar Bermans J, Tyler-Kabara Elizabeth C, Daniels David J, Jackson Eric M, Grant Gerald A, Couture Daniel E, Adelson P David, Alden Tord D, Aldana Philipp R, Anderson Richard C E, Selden Nathan R, Baird Lissa C, Bierbrauer Karin, Chern Joshua J, Whitehead William E, Ellenbogen Richard G, Fuchs Herbert E, Guillaume Daniel J, Hankinson Todd C, Iantosca Mark R, Oakes W Jerry, Keating Robert F, Khan Nickalus R, Muhlbauer Michael S, McComb J Gordon, Menezes Arnold H, Ragheb John, Smith Jodi L, Maher Cormac O, Greene Stephanie, Kelly Michael, O'Neill Brent R, Krieger Mark D, Tamber Mandeep, Durham Susan R, Olavarria Greg, Stone Scellig S D, Kaufman Bruce A, Heuer Gregory G, Bauer David F, Albert Gregory, Greenfield Jeffrey P, Wait Scott D, Van Poppel Mark D, Eskandari Ramin, Mapstone Timothy, Shimony Joshua S, Dacey Ralph G, Smyth Matthew D, Park Tae Sung, Limbrick David D
Аннотация
METHODS: A large multicenter retrospective and prospective registry of pediatric patients with CM-I (tonsils ≥ 5 mm below the foramen magnum) and syrinx (≥ 3 mm in axial width) was reviewed for clinical and radiological characteristics of CM-I, syrinx, and scoliosis (coronal curve ≥ 10°).
RESULTS: Based on available imaging of patients with CM-I and syrinx, 260 of 825 patients (31%) had a clear diagnosis of scoliosis based on radiographs or coronal MRI. Forty-nine patients (5.9%) did not have scoliosis, and in 516 (63%) patients, a clear determination of the presence or absence of scoliosis could not be made. Comparison of patients with and those without a definite scoliosis diagnosis indicated that scoliosis was associated with wider syrinxes (8.7 vs 6.3 mm, OR 1.25, p < 0.001), longer syrinxes (10.3 vs 6.2 levels, OR 1.18, p < 0.001), syrinxes with their rostral extent located in the cervical spine (94% vs 80%, OR 3.91, p = 0.001), and holocord syrinxes (50% vs 16%, OR 5.61, p < 0.001). Multivariable regression analysis revealed syrinx length and the presence of holocord syrinx to be independent predictors of scoliosis in this patient cohort. Scoliosis was not associated with sex, age at CM-I diagnosis, tonsil position, pB-C2 distance (measured perpendicular distance from the ventral dura to a line drawn from the basion to the posterior-inferior aspect of C2), clivoaxial angle, or frontal-occipital horn ratio. Average curve magnitude was 29.9°, and 37.7% of patients had a left thoracic curve. Older age at CM-I or syrinx diagnosis (p < 0.0001) was associated with greater curve magnitude whereas there was no association between syrinx dimensions and curve magnitude.
CONCLUSIONS: Syrinx characteristics, but not tonsil position, were related to the presence of scoliosis in patients with CM-I, and there was an independent association of syrinx length and holocord syrinx with scoliosis. Further study is needed to evaluate the nature of the relationship between syrinx and scoliosis in patients with CM-I.