European journal of pharmacology · 2021
SARS-CoV-2 attenuates corticosteroid sensitivity by suppressing DUSP1 expression and activating p38 MAPK pathway.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Saheb Sharif-Askari Fatemeh, Saheb Sharif-Askari Narjes, Goel Swati, Hafezi Shirin, Assiri Rasha, Al-Muhsen Saleh, Hamid Qutayba, Halwani Rabih
Аннотация
The efficacy of corticosteroids and its use for the treatment of SARS-CoV-2 infections is controversial. In this study, using data sets of SARS-CoV-2 infected lung tissues and nasopharyngeal swabs, as well as in vitro experiments, we show that SARS-CoV-2 infection significantly downregulates DUSP1 expression. This downregulation of DUSP1 could be the mechanism regulating the enhanced activation of MAPK pathway as well as the reported steroid resistance in SARS-CoV-2 infection. Moreover, chloroquine, an off labeled COVID-19 drug is able to induce DUSP1 and attenuate MAPK pathway; and is expected to improve sensitivity to steroid treatment. However, further mechanistic studies are required to confirm this effect.
Предметные рубрики MeSH
AdultAgedCOVID-19Case-Control StudiesCells, CulturedChloroquineDatasets as TopicDown-RegulationDrug ResistanceDrug SynergismDual Specificity Phosphatase 1FibroblastsGlucocorticoidsHealthy VolunteersHumansLungMAP Kinase Signaling SystemMiddle AgedNasopharynxOff-Label UsePrimary Cell CultureSARS-CoV-2p38 Mitogen-Activated Protein KinasesCOVID-19 Drug Treatment