PloS one · 2025
Physiology of body lateralization on regional lung ventilation and lung volumes in healthy subjects: Within-subjects design.
СтатьяМногоцентровое исследованиеРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Costa Layane S P, Reinaux Cyda M A, Júnior Emanuel F F Silva, Leite Wagner S, Brandão Daniella C, de Andrade Armèle Dornelas, Roldán Rollin, Morais Caio C A, Campos Shirley Lima
Аннотация
INTRODUCTION: Lateral positioning improves pulmonary mechanics and lung volumes, but its effects in healthy adults remain unclear due to individual variability.
OBJECTIVE: To analyze the acute effects of lateral body positioning on regional lung ventilation and lung volumes in healthy adults.
METHODS: This within-subject study included two protocols: supine and left-lateral position (unilateral) with repeated measures and supine, left, and right-lateral positions (bilateral). All positions were performed at 30° for 5 minutes on an automated rotation bed. Electrical Impedance Tomography measured regional lung ventilation (%) and end-expiratory lung volumes (EELV) across four lung regions: (anterior right [AR] and left [AL]; posterior right [PR], and left [PL]). Linear mixed models assessed the influence of body position and individual variability on regional ventilation and lung volumes, while the Restricted Maximum Likelihood method compared between right- and left-lateral positioning.
RESULTS: In the unilateral protocol (n = 29; 58.6% male; 22.8 ± 4.0 years), left-lateral positioning decreased regional ventilation in nondependent regions (AR: -0.96%, PR: -1.63%) and increased it in dependent regions (PL: 1.17%, AL: 1.42%) versus supine (p < 0.001). EELV increased in PL (+ 0.7 mL/kg PBW), PR (+2.0), and AR (+2.8), but decreased in AL (-2.3) (p < 0.001). In the bilateral protocol (n = 10, 70% male; 23.6 ± 3.2 years), regional ventilation showed no significant effects of position, ROI, or interaction (p > 0.05). However, EELV varied significantly with body position (p < 0.001), with no isolated ROI effect (p = 1.000).
CONCLUSIONS: Lateral positioning improves regional ventilation in dependent lung regions and increases EELV in nondependent and posterior dependent lung regions, regardless of side.
TRIAL REGISTRATION: ClinicalTrials.gov [NCT06044896].
OBJECTIVE: To analyze the acute effects of lateral body positioning on regional lung ventilation and lung volumes in healthy adults.
METHODS: This within-subject study included two protocols: supine and left-lateral position (unilateral) with repeated measures and supine, left, and right-lateral positions (bilateral). All positions were performed at 30° for 5 minutes on an automated rotation bed. Electrical Impedance Tomography measured regional lung ventilation (%) and end-expiratory lung volumes (EELV) across four lung regions: (anterior right [AR] and left [AL]; posterior right [PR], and left [PL]). Linear mixed models assessed the influence of body position and individual variability on regional ventilation and lung volumes, while the Restricted Maximum Likelihood method compared between right- and left-lateral positioning.
RESULTS: In the unilateral protocol (n = 29; 58.6% male; 22.8 ± 4.0 years), left-lateral positioning decreased regional ventilation in nondependent regions (AR: -0.96%, PR: -1.63%) and increased it in dependent regions (PL: 1.17%, AL: 1.42%) versus supine (p < 0.001). EELV increased in PL (+ 0.7 mL/kg PBW), PR (+2.0), and AR (+2.8), but decreased in AL (-2.3) (p < 0.001). In the bilateral protocol (n = 10, 70% male; 23.6 ± 3.2 years), regional ventilation showed no significant effects of position, ROI, or interaction (p > 0.05). However, EELV varied significantly with body position (p < 0.001), with no isolated ROI effect (p = 1.000).
CONCLUSIONS: Lateral positioning improves regional ventilation in dependent lung regions and increases EELV in nondependent and posterior dependent lung regions, regardless of side.
TRIAL REGISTRATION: ClinicalTrials.gov [NCT06044896].