Oral surgery, oral medicine, oral pathology and oral radiology · 2025
Cocamidopropyl betaine: another possible oral healthcare chemical associated with plasma cell lesions of the oral cavity.
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Saepoo Jay, Handoo Nidhi, Timmons Sherry, Lanzel Emily, Tikkhanarak Kittiphoj, Hellstein John William
Аннотация
OBJECTIVE: To examine the apparent increase in plasma cell lesions of the oral cavity over the course of the past two decades and to propose a possible explanation and therapeutic approach for a subset of these cases.
STUDY DESIGN: Data from cases evaluated at the University of Iowa Surgical Oral Pathology Laboratory (UI-SOP) between July 2003 and May 2024 were retrospectively reviewed to analyze demographics, clinical presentations, and trends in the incidence of these lesions. Additionally, a subset of clinical cases seen at the Oral Pathology Clinic from 2023 to 2024 was examined to explore a potential association with the use of cocamidopropyl betaine (CAPB)-containing toothpaste.
RESULTS: A total of 61 cases were retrieved from UI-SOP archive and analyzed. An increase in the histopathologic diagnoses of oral plasma cell lesions was observed. The clinical case series would seem to indicate CAPB as a possible additional chemical associated with plasma cell gingivitis.
CONCLUSIONS: Eliminating the CAPB-containing toothpaste appeared to be a predictable reason for resolution of the gingival/mucosal phenotype in multiple patients. Further collection of cases in a controlled prospective manner may be helpful in confirming the association.
STUDY DESIGN: Data from cases evaluated at the University of Iowa Surgical Oral Pathology Laboratory (UI-SOP) between July 2003 and May 2024 were retrospectively reviewed to analyze demographics, clinical presentations, and trends in the incidence of these lesions. Additionally, a subset of clinical cases seen at the Oral Pathology Clinic from 2023 to 2024 was examined to explore a potential association with the use of cocamidopropyl betaine (CAPB)-containing toothpaste.
RESULTS: A total of 61 cases were retrieved from UI-SOP archive and analyzed. An increase in the histopathologic diagnoses of oral plasma cell lesions was observed. The clinical case series would seem to indicate CAPB as a possible additional chemical associated with plasma cell gingivitis.
CONCLUSIONS: Eliminating the CAPB-containing toothpaste appeared to be a predictable reason for resolution of the gingival/mucosal phenotype in multiple patients. Further collection of cases in a controlled prospective manner may be helpful in confirming the association.