International dental journal · 2025
Association Between Helicobacter Pylori Infection and Periodontal and Gastric Diseases: A Meta-Analysis.
СтатьяМетаанализНазвание и аннотация: Перевод пока не подготовлен
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Liu Qinghua, Zhang Ying, Qi Fengxiang
Аннотация
BACKGROUND: Helicobacter pylori (Hp) infection has been implicated in both gastric and extra-gastric diseases, including periodontitis.
METHODS: This meta-analysis investigated the association between Helicobacter pylori (Hp) infection and periodontitis by systematically reviewing eight studies. The analysis was conducted using the R package "meta," employing both fixed effects and random effects models. The level of heterogeneity among the studies was assessed using the I-squared statistic and tau values. Publication bias was evaluated through funnel plots, Begg's rank correlation, and Egger's regression tests to ensure the robustness of the findings.
RESULTS: The meta-analysis included a total of 6061 observations, with 1404 cases of periodontitis. The fixed effects model produced an odds ratio (OR) of 2.3392 (95% confidence interval [CI]: 2.0207-2.7078), and the random effects model yielded a similar OR of 2.3220 (95% CI: 2.0050-2.6892). The I-squared statistic indicated low to moderate heterogeneity among the studies. Subgroup analyses demonstrated consistent associations across different Hp diagnostic methods.
CONCLUSION: Hp infection is significantly associated with an increased risk of periodontitis, highlighting its role in both gastric and oral health.
METHODS: This meta-analysis investigated the association between Helicobacter pylori (Hp) infection and periodontitis by systematically reviewing eight studies. The analysis was conducted using the R package "meta," employing both fixed effects and random effects models. The level of heterogeneity among the studies was assessed using the I-squared statistic and tau values. Publication bias was evaluated through funnel plots, Begg's rank correlation, and Egger's regression tests to ensure the robustness of the findings.
RESULTS: The meta-analysis included a total of 6061 observations, with 1404 cases of periodontitis. The fixed effects model produced an odds ratio (OR) of 2.3392 (95% confidence interval [CI]: 2.0207-2.7078), and the random effects model yielded a similar OR of 2.3220 (95% CI: 2.0050-2.6892). The I-squared statistic indicated low to moderate heterogeneity among the studies. Subgroup analyses demonstrated consistent associations across different Hp diagnostic methods.
CONCLUSION: Hp infection is significantly associated with an increased risk of periodontitis, highlighting its role in both gastric and oral health.