Clinical Outcomes of Periodontal Regenerative Therapy Utilizing the Double-Sided Entire Papilla Preservation (DEPP) Technique for Infrabony Defects: A 12-Month Follow-up Case Series.

The Double-sided Entire Papilla Preservation (DEPP) technique was designed to allow access into a bone defect without compromising the integrity of the papilla when the defect extends to the palatal/ lingual side. This case series aimed to evaluate the clinical and radiographic outcomes of periodontal regenerative therapy using the DEPP technique for infrabony defects. DEPP was performed with vertical incisions on both the buccal and palatal sides to access the bone defect. After debridement, recombinant human fibroblast growth factor-2 or enamel matrix derivative was used in combination with carbonate apatite or deproteinized bovine bone mineral to treat the defect. Periodontal parameters were evaluated at baseline and at 6 and 12 months postoperatively. Clinical attachment level (CAL) and probing depth (PD) values were significantly improved compared to baseline at 6 months (P < .05) and 12 months (P < .01). At 12 months, the mean PD reduction was 5.0 ± 1.4 mm and CAL gain was 5.3 ± 1.8 mm. According to the composite outcome measure, the outcomes of the treated sites were considered successful. This case series demonstrates that DEPP can be effectively combined with regenerative therapy for the treatment of infrabony defects that extend to the palatal/lingual side, yielding favorable clinical outcomes with minimal surgical complications.