Pleomorphic Giant Cell Carcinoma and Periurethral Abscess: A Case Report.

Prostate cancer (PCa) is the most common solid malignancy in men in the UK. Pleomorphic giant cell carcinoma (PGCC) is a rare, aggressive variant of prostate adenocarcinoma. PGCC is associated with a poor prognosis and high Gleason-grade characteristics, often occurring in patients with a history of PCa treatment. This case report details the presentation of a 78-year-old male with a background of PCa, previously treated with radiotherapy and androgen deprivation therapy, who was initially diagnosed with a periurethral abscess. Despite initial treatment, the patient experienced recurrent symptoms, leading to further investigations and surgical intervention. Histopathological analysis of tissue samples revealed PGCC, highlighting the importance of considering this malignancy in cases of recurrent abscesses in patients with a history of PCa. This case underscores the necessity of early suspicion, prompt investigation, and multidisciplinary management in complex cases involving PGCC, emphasizing the need for heightened awareness of this rare pathology in clinical practice.