Oncology · 2016
Prognostic Factors and Multidisciplinary Postoperative Chemoradiotherapy for Clinical T4a Tongue Cancer.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Yokota Tomoya, Iida Yoshiyuki, Ogawa Hirofumi, Kamijo Tomoyuki, Onozawa Yusuke, Todaka Akiko, Hamauchi Satoshi, Onoe Tsuyoshi, Nakagawa Masahiro, Yurikusa Takashi, Tanuma Akira, Yamashita Aiko, Nishimura Tetsuo, Yasui Hirofumi, Onitsuka Tetsuro
Аннотация
OBJECTIVE: The prognosis of patients with locally advanced squamous cell carcinoma (SCC) of the tongue is poor. Postoperative chemoradiotherapy (CRT) improves locoregional control and survival in high-risk patients. We investigated the prognostic factors for clinical T4a tongue SCC, and elucidated whether postoperative CRT has a benefit for patients with poor prognosis in terms of survival.
METHODS: We performed a retrospective analysis of 61 patients with stage T4a SCC of the tongue who underwent primary resection and neck dissection.
RESULTS: The median follow-up was 53.8 months. Multivariate analysis revealed a 4.26× relative risk of death for patients with the involvement of ≥5 regional lymph nodes (pN ≥5) compared with those with pN 0-4 (p = 0.002). In Kaplan-Meier analysis, patients with pN ≥5 who received CRT had longer overall survival rates than those who did not (hazard ratio = 0.31; p = 0.041).
CONCLUSIONS: pN ≥5 is the most powerful prognostic factor for clinical T4a SCC of the tongue. Postoperative CRT is recommended in patients with pN ≥5.
METHODS: We performed a retrospective analysis of 61 patients with stage T4a SCC of the tongue who underwent primary resection and neck dissection.
RESULTS: The median follow-up was 53.8 months. Multivariate analysis revealed a 4.26× relative risk of death for patients with the involvement of ≥5 regional lymph nodes (pN ≥5) compared with those with pN 0-4 (p = 0.002). In Kaplan-Meier analysis, patients with pN ≥5 who received CRT had longer overall survival rates than those who did not (hazard ratio = 0.31; p = 0.041).
CONCLUSIONS: pN ≥5 is the most powerful prognostic factor for clinical T4a SCC of the tongue. Postoperative CRT is recommended in patients with pN ≥5.
Предметные рубрики MeSH
AgedAntimetabolites, AntineoplasticAntineoplastic AgentsCarcinoma, Squamous CellChemoradiotherapy, AdjuvantChemotherapy, AdjuvantCisplatinDrug CombinationsFemaleHumansLymph NodesLymphatic MetastasisMaleMiddle AgedNeck DissectionNeoplasm StagingOxonic AcidPatient Care TeamPostoperative CarePrognosisRadiotherapy, AdjuvantRetrospective StudiesSurvival RateTegafurTongue Neoplasms