European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016
Does securin expression have significance in prognostication of oral tongue cancer? A pilot study.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Heikkinen Ilkka, Almangush Alhadi, Hagström Jaana, Bello Ibrahim O, Kauppila Joonas H, Mäkinen Laura K, Haglund Caj, Nieminen Pentti, Salo Tuula, Leivo Ilmo
Аннотация
The proliferation marker, securin, is involved in the progression of many carcinomas. However, its expression in oral tongue squamous cell carcinoma (OTSCC) has not been previously studied. We examined securin expression by immunohistochemistry in OTSCC. A total of 93 cases treated for OTSCC were included in this study. Expression of securin in OTSCC was studied by immunohistochemistry of tissue microarrays (52 cases) and routine tumor sections (41 cases). Securin overexpression is significantly associated with higher tumor grade (P = 0.03). Overexpression of securin was observed more frequently in advanced stages of OTSCC than in earlier stages but the difference was not statistically significant. These findings suggest that overexpression of securin in OTSCC may be important during progression of this cancer. No significant association was found between securin expression and the prognosis of OTSCC.