American journal of veterinary research · 2025
Relationship between external jugular and central venous oxygen saturation in anesthetized dogs under varying hemodynamic conditions.
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Lee Nanju, Namgoong Beomkwan, Seo Daeyun, Lim Seongsoo, Kim Isong, Heo Seunghun, Kang Jihwan, Kim Cheyoun, Shin Hayoung, Park Soyeon, Park Jaewon, Kim Min-Su
Аннотация
OBJECTIVE: To assess the correlation, agreement, and trending ability between external jugular venous oxygen saturation (SejvO2) and central venous oxygen saturation (ScvO2) across varying hemodynamic states in anesthetized dogs.
METHODS: This prospective, nonrandomized, repeated-measures study included 6 healthy dogs. Each dog was anesthetized, paralyzed, and mechanically ventilated. Six sequential hemodynamic states were induced: baseline, controlled hemorrhage, isotonic crystalloid resuscitation, autotransfusion, continuous rate infusion of dobutamine, and administration of high-concentration isoflurane. Simultaneous blood samples were collected from a central venous catheter and an external jugular venous catheter. Paired SejvO2 and ScvO2 values were analyzed for correlation, agreement, and trending ability.
RESULTS: 36 paired samples were obtained. External jugular venous oxygen saturation and ScvO2 were strongly correlated (r = 0.71; 95% CI, 0.50 to 0.84). Bland-Altman analysis showed a mean bias of -4.47% (95% CI, -7.34% to -1.60%) with limits of agreement from -14.25% (95% CI, -17.70% to -10.81%) to 5.31% (95% CI, 1.87% to 8.76%), exceeding the predefined ± 8% threshold. The concordance rate was 66.7% (95% CI, 47.2% to 82.7%) and improved to 87.5% (95% CI, 61.7% to 98.4%) when applying an exclusion zone of ± 5%, indicating moderate trending ability.
CONCLUSIONS: SejvO2 correlated strongly with ScvO2 but lacked sufficient agreement for direct substitution. However, it demonstrated moderate ability to track directional changes under different hemodynamic conditions.
CLINICAL RELEVANCE: SejvO2 may serve as a less invasive option for serial monitoring of oxygen balance when direct ScvO2 measurement is not feasible, supporting its potential role in critical care monitoring.
METHODS: This prospective, nonrandomized, repeated-measures study included 6 healthy dogs. Each dog was anesthetized, paralyzed, and mechanically ventilated. Six sequential hemodynamic states were induced: baseline, controlled hemorrhage, isotonic crystalloid resuscitation, autotransfusion, continuous rate infusion of dobutamine, and administration of high-concentration isoflurane. Simultaneous blood samples were collected from a central venous catheter and an external jugular venous catheter. Paired SejvO2 and ScvO2 values were analyzed for correlation, agreement, and trending ability.
RESULTS: 36 paired samples were obtained. External jugular venous oxygen saturation and ScvO2 were strongly correlated (r = 0.71; 95% CI, 0.50 to 0.84). Bland-Altman analysis showed a mean bias of -4.47% (95% CI, -7.34% to -1.60%) with limits of agreement from -14.25% (95% CI, -17.70% to -10.81%) to 5.31% (95% CI, 1.87% to 8.76%), exceeding the predefined ± 8% threshold. The concordance rate was 66.7% (95% CI, 47.2% to 82.7%) and improved to 87.5% (95% CI, 61.7% to 98.4%) when applying an exclusion zone of ± 5%, indicating moderate trending ability.
CONCLUSIONS: SejvO2 correlated strongly with ScvO2 but lacked sufficient agreement for direct substitution. However, it demonstrated moderate ability to track directional changes under different hemodynamic conditions.
CLINICAL RELEVANCE: SejvO2 may serve as a less invasive option for serial monitoring of oxygen balance when direct ScvO2 measurement is not feasible, supporting its potential role in critical care monitoring.