Transplant infectious disease : an official journal of the Transplantation Society · 2025
Limited Risk of Microbial Contamination During Hypothermic and Normothermic Machine Perfusion of Donor Kidneys.
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Slagter Julia S, Schurink Carolina A M, Chong Ga-Lai M, Reinders Marlies E J, Porte Robert J, Minnee Robert C
Аннотация
BACKGROUND: Both hypothermic machine perfusion (HMP) and normothermic machine perfusion (NMP) are increasingly used for preservation of deceased donor kidneys. However, especially NMP can pose as a risk for microbial contamination of the kidney graft as the 37°C perfusate can act as a breeding ground for microbial contaminants.
METHODS: In this study, we investigated the cultures of HMP and NMP perfusates of deceased donor kidneys.
RESULTS: Between January 2021 and April 2024, a total of 99 perfusates were examined (73 HMP and 26 NMP perfusates)-. We found that contamination of HMP perfusate was common, occurring in 21 of 73 cultures (29%). Most bacteria originated from the skin. Microbial contamination during NMP was rare, occurring only in 2 of 26 cultures (8%). Microbial contamination during machine perfusion did not lead to infectious complications in the recipients.
CONCLUSION: Machine perfusion poses a very limited risk of infection in kidney transplant recipients.
METHODS: In this study, we investigated the cultures of HMP and NMP perfusates of deceased donor kidneys.
RESULTS: Between January 2021 and April 2024, a total of 99 perfusates were examined (73 HMP and 26 NMP perfusates)-. We found that contamination of HMP perfusate was common, occurring in 21 of 73 cultures (29%). Most bacteria originated from the skin. Microbial contamination during NMP was rare, occurring only in 2 of 26 cultures (8%). Microbial contamination during machine perfusion did not lead to infectious complications in the recipients.
CONCLUSION: Machine perfusion poses a very limited risk of infection in kidney transplant recipients.