Journal of clinical lipidology · 2025
Obesity, abdominal obesity, and adipose tissue depots in South Asians with specific reference to Asian Indians: Implications of New Obesity Guidelines.
СтатьяОбзорНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Misra Anoop, Anoop Shajith, Sharma Sushum
Аннотация
BACKGROUND: This review explores the distinct metabolic phenotype prevalent among South Asians, marked by a "normal BMI-high body and abdominal fat-low muscle mass" profile that carries significant health implications. We discuss obesity, abdominal adiposity, body fat depots, and new obesity guidelines applicable to Asian Indians.
SOURCES OF MATERIAL: Current evidence is drawn from population-based and clinical studies among South Asians, as well as recent updates from international guidelines, including the Lancet Obesity Commission and ethnicity-specific recommendations for Asian Indians.
ABSTRACT OF FINDINGS: Compared to Caucasians, South Asians exhibit unique patterns of adipose tissue distribution. At similar BMI levels, they tend to have a higher body fat percentage, increased abdominal adiposity, and greater subcutaneous abdominal adipose tissue. A key feature of this pattern is the limited capacity for subcutaneous fat storage, leading to fat deposition in ectopic sites such as the liver and pancreas. These characteristics result in elevated cardiometabolic risk at lower BMI thresholds, highlighting the need for population-specific diagnostic criteria. The recently updated global guidelines from the Lancet Obesity Commission propose a two-stage obesity classification system that goes beyond BMI, incorporating assessments of functional impairment and comorbidities. For Asian Indians, corresponding new guidelines define Stage 1 obesity (BMI ≥23 kg/m2 without excess abdominal adiposity or complications) as a condition primarily managed with lifestyle modifications. In contrast, Stage 2 obesity-marked by abdominal obesity, functional limitations, or comorbidities-warrants more intensive interventions, including early pharmacotherapy.
CONCLUSION: These ethnicity-specific frameworks should be adapted across South Asian countries to enable precise clinical evaluation, effective risk stratification, and targeted treatment strategies tailored to this high-risk population.
SOURCES OF MATERIAL: Current evidence is drawn from population-based and clinical studies among South Asians, as well as recent updates from international guidelines, including the Lancet Obesity Commission and ethnicity-specific recommendations for Asian Indians.
ABSTRACT OF FINDINGS: Compared to Caucasians, South Asians exhibit unique patterns of adipose tissue distribution. At similar BMI levels, they tend to have a higher body fat percentage, increased abdominal adiposity, and greater subcutaneous abdominal adipose tissue. A key feature of this pattern is the limited capacity for subcutaneous fat storage, leading to fat deposition in ectopic sites such as the liver and pancreas. These characteristics result in elevated cardiometabolic risk at lower BMI thresholds, highlighting the need for population-specific diagnostic criteria. The recently updated global guidelines from the Lancet Obesity Commission propose a two-stage obesity classification system that goes beyond BMI, incorporating assessments of functional impairment and comorbidities. For Asian Indians, corresponding new guidelines define Stage 1 obesity (BMI ≥23 kg/m2 without excess abdominal adiposity or complications) as a condition primarily managed with lifestyle modifications. In contrast, Stage 2 obesity-marked by abdominal obesity, functional limitations, or comorbidities-warrants more intensive interventions, including early pharmacotherapy.
CONCLUSION: These ethnicity-specific frameworks should be adapted across South Asian countries to enable precise clinical evaluation, effective risk stratification, and targeted treatment strategies tailored to this high-risk population.