Wei sheng yan jiu = Journal of hygiene research · 2025
[Detection and exposure risk assessment of chloropropanol ester and glycidyl ester in infant formula milk powder].
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He Huali, Fan Jicai, Wang Dafang, Bian Tianbin, Ren Ren
Аннотация
OBJECTIVE: To investigate the contamination level of chloropropanols esters(MCPDEs) and glycidyl esters(GEs) in infant milk powder, and to assess the risk of exposure to MCPDEs and GEs in infant formula milk powder in Hangzhou.
METHODS: Non-derivatization gas chromatography-tandem mass spectrometry(GC-MS/MS) was used to detect MCPDEs in 73 samples of commercially available infant milk powder, including 3-chlorine-1, 2-propylene glycol ester, 3-MCPDE), 2-monochloropropane-1, 3 diol esters(2-MCPDE) and GEs. Dietary exposure assessment of chloropropanols esters and glycidyl esters were evaluated by evaluation method and margin of exposure(MOE) respectively.
RESULTS: The detection rates of 3-MCPDE, 2-MCPDE and GEs were 100.0%, 82.2% and 78.1%. The average detection concentrations were 0.051, 0.015 and 0.018 mg/kg, respectively. The average and P95 dietary exposure values for 3-MCPDE were 0.48-1.41 and 0.81-2.69 μg/(kg·BW·d). For GEs, these were 24 669-58 945 and 10 881-21 540 respectively.
CONCLUSION: The median exposure value of 3-MCPDE in infant milk powder is less than the TDI, and the health risk is small. But the P95 value of 3-MCPDE for infant aged 0-6 months is 2.69 μg/(kg·BW·d), greater than TDI value, so high health risk exists. The MOE for infants aged 0-6 months is lower than 25 000, and it may pose a potential risk. The MOE for children aged 6-36 months is higher than 25 000, and the health risk is very low.
METHODS: Non-derivatization gas chromatography-tandem mass spectrometry(GC-MS/MS) was used to detect MCPDEs in 73 samples of commercially available infant milk powder, including 3-chlorine-1, 2-propylene glycol ester, 3-MCPDE), 2-monochloropropane-1, 3 diol esters(2-MCPDE) and GEs. Dietary exposure assessment of chloropropanols esters and glycidyl esters were evaluated by evaluation method and margin of exposure(MOE) respectively.
RESULTS: The detection rates of 3-MCPDE, 2-MCPDE and GEs were 100.0%, 82.2% and 78.1%. The average detection concentrations were 0.051, 0.015 and 0.018 mg/kg, respectively. The average and P95 dietary exposure values for 3-MCPDE were 0.48-1.41 and 0.81-2.69 μg/(kg·BW·d). For GEs, these were 24 669-58 945 and 10 881-21 540 respectively.
CONCLUSION: The median exposure value of 3-MCPDE in infant milk powder is less than the TDI, and the health risk is small. But the P95 value of 3-MCPDE for infant aged 0-6 months is 2.69 μg/(kg·BW·d), greater than TDI value, so high health risk exists. The MOE for infants aged 0-6 months is lower than 25 000, and it may pose a potential risk. The MOE for children aged 6-36 months is higher than 25 000, and the health risk is very low.