Nuklearmedizin. Nuclear medicine · 2026
FDG-PET/CT in children with malignant diseases - comparison of a long axial field of view scanner with a standard scanner.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Bosbach Wolfram A, Manser Valentin, Bregenzer Carola M, Gözlügöl Nasir, Krieger Korbinian, Zeimpekis Konstantinos, Mendes Angela Filipa Silva, Engelbrecht Swantje, Felgosa Cardoso Angelo R, Shi Kuangyu, Rominger Axel, Sari Hasan, Cumming Paul, Mingels Clemens, Afshar-Oromieh Ali
Аннотация
AIM: [18F]FDG positron-emission-tomography/computed tomography (PET/CT) is a crucial tool in paediatric oncology for staging, treatment response assessment, and follow-up imaging. Long axial field of view (LAFOV) PET/CT is more sensitive for the detection of annihilation events than short axial field of view (SAFOV) instrumentation, thus enabling lower radiation dose and/or briefer acquisition time. In consideration of the radiation sensitivity of children, we compared the performance of LAFOV and SAFOV PET/CT in paediatric oncology.
METHODS: Twenty-six paediatric oncology patients (mean age 13.7 ± 4.8 y), of whom half had diagnosis of lymphoma, underwent 37 [18F]FDG PET/CT scans (12 SAFOV, 25 LAFOV). The LAFOV acquisitions (1-3 MBq/kg) were numerically rescaled to simulate 0.5-3 MBq/kg, yielding 75 LAFOV studies. Four blinded readers rated image quality on a 5-point Likert scale, and recorded various imaging metrics, statistical comparison, and power calculations.
RESULTS: LAFOV at 2 and 3 MBq/kg achieved significantly higher Likert ratings than SAFOV. LAFOV at 1 MBq/kg yielded comparable ratings to SAFOV (p=0.13), while 0.5 MBq/kg was inferior to SAFOV (p=0.012). Hepatic background SD decreased and SNR increased dose-dependently with LAFOV (p<0.001), whereas lesion SUVmax and SUVmean remained stable across scanners. TBR was lower for LAFOV at higher doses, despite unchanged image quality. Inter-rater agreement was fair to moderate.
CONCLUSION: LAFOV PET/CT supports [18F]FDG dose reduction without impairing image quality for lesion detection. 1 MBq/kg yielded diagnostic quality comparable to SAFOV, while 2-3 MBq/kg provided superior performance. These results support LAFOV PET/CT as a strategy to minimize radiation exposure in children.
METHODS: Twenty-six paediatric oncology patients (mean age 13.7 ± 4.8 y), of whom half had diagnosis of lymphoma, underwent 37 [18F]FDG PET/CT scans (12 SAFOV, 25 LAFOV). The LAFOV acquisitions (1-3 MBq/kg) were numerically rescaled to simulate 0.5-3 MBq/kg, yielding 75 LAFOV studies. Four blinded readers rated image quality on a 5-point Likert scale, and recorded various imaging metrics, statistical comparison, and power calculations.
RESULTS: LAFOV at 2 and 3 MBq/kg achieved significantly higher Likert ratings than SAFOV. LAFOV at 1 MBq/kg yielded comparable ratings to SAFOV (p=0.13), while 0.5 MBq/kg was inferior to SAFOV (p=0.012). Hepatic background SD decreased and SNR increased dose-dependently with LAFOV (p<0.001), whereas lesion SUVmax and SUVmean remained stable across scanners. TBR was lower for LAFOV at higher doses, despite unchanged image quality. Inter-rater agreement was fair to moderate.
CONCLUSION: LAFOV PET/CT supports [18F]FDG dose reduction without impairing image quality for lesion detection. 1 MBq/kg yielded diagnostic quality comparable to SAFOV, while 2-3 MBq/kg provided superior performance. These results support LAFOV PET/CT as a strategy to minimize radiation exposure in children.