The American journal of gastroenterology · 2021
Achalasia Is Associated With Atopy in Patients Younger Than 40 Years of Age.
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King Dominic, Thomas Tom, Chandan Joht Singh, Bhala Nij, Adderley Nicola J, Nirantharakumar Krishnarajah, Trudgill Nigel
Аннотация
INTRODUCTION: Case reports describe individuals with achalasia features subsequently diagnosed with eosinophilic esophagitis (an atopic disorder). We have examined associations between achalasia and atopic and autoimmune conditions.
METHODS: This is a UK cohort study of 2,593 subjects with achalasia matched to 10,402 controls.
RESULTS: At diagnosis, achalasia was associated with autoimmune conditions (odds ratio 1.39; 95% confidence interval 1.02-1.90) and atopic conditions (1.40; 1.00-1.95) in those aged younger than 40 years.
DISSCUSSION: Our findings support an autoimmune etiology in achalasia but also suggest a possible atopic etiology in younger subjects.
METHODS: This is a UK cohort study of 2,593 subjects with achalasia matched to 10,402 controls.
RESULTS: At diagnosis, achalasia was associated with autoimmune conditions (odds ratio 1.39; 95% confidence interval 1.02-1.90) and atopic conditions (1.40; 1.00-1.95) in those aged younger than 40 years.
DISSCUSSION: Our findings support an autoimmune etiology in achalasia but also suggest a possible atopic etiology in younger subjects.