SERF-MEG as a Functional Biomarker of Optic Nerve Injury: Agreement and Correlation with Visual Evoked Potentials.

This study assessed the cross-modal agreement between spin-exchange relaxation-free magnetoencephalography (SERF-MEG) and conventional visual evoked potentials (VEPs) in patients with optic nerve injury using comparable pattern-reversal visual stimulation paradigms. Forty-five patients with optic neuritis (ON), ischemic optic neuropathy (ION), and traumatic optic neuropathy (TON) were enrolled, and a paired-eye design was applied to assess interocular electrophysiological changes between the affected and fellow eyes. Both modalities indicated consistent impairment of visual pathway function, reflected by reduced response amplitudes and prolonged latencies. For latency measures, MEG-derived M100 showed moderate directional concordance and a significant correlation with VEP P100, whereas amplitude measures demonstrated similar directional changes but limited quantitative correlations across modalities. Compared with the MaxP2P method, the channel-averaged method displayed higher stability and cross-modal concordance. These findings show that SERF-MEG can capture clinically relevant visual pathway impairment and may complement conventional VEP by providing additional information on cortical response patterns. Overall, SERF-MEG shows potential as an objective functional biomarker for neuro-ophthalmic assessment of optic nerve injury.