Forensic significance of quantitatively analyzing methamphetamine in male reproductive organs.

The present study measured concentrations of methamphetamine (MA) and its metabolite amphetamine (AMP) in male reproductive organs and investigated the significance of detecting these stimulants in the reproductive organs and the associated pharmacokinetics. The study examined the left and right testes and prostate from 28 male autopsy cases in which MA had been detected. Concentrations of MA and AMP in the left and right testes and prostate were quantified and compared with concentrations in right heart blood, iliac vein blood, and urine. No correlations were found between MA or AMP concentrations and post-mortem time at any sampling sites. MA and AMP concentrations in the left and right testes correlated with concentrations in iliac vein blood, but not with concentrations in urine. Conversely, MA and AMP concentrations in the prostate did not correlate with concentrations in any body fluid samples. Concentrations of MA were much higher in the left and right testes and prostate than in right heart and iliac vein blood (median, about 3-5 times higher). Concentrations of AMP were also much higher in the left and right testes and prostate than in right heart and iliac vein blood (median, about 2-3 times higher). In conclusion, this study revealed that MA and AMP were detected in the left and right testes and prostate at median concentrations about 2-5 times higher than those in blood.