Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2007
[Effects of Porphyromonas gingivalis lipopolysaccharide on collagen phagocytosis by human periodontal ligament fibroblasts].
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Fang Chang-yun, Su Zheng, Chen Lei, Fan Ming-wen, Jian Xin-chun, Chen Zhi
Аннотация
OBJECTIVE: To investigate the effects of Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide (LPS) on collagen phagocytosis of human periodontal ligament fibroblasts (hPDLF).
METHODS: Fluorescence localization and flow cytometry was used to test the collagen phygocytosis of hPDLF stimulated by the various concentration of LPS for 48 hours in vitro.
RESULTS: The collagen phygocytosis of hPDLF was increased significantly by 0.1 microg/mL LPS (P < 0.05).
CONCLUSION: This study indicates that P. gingivalis LPS may enhance the degradation of collagen by stimulating the phagocytic activity of the hPDLF in periodontitis.
METHODS: Fluorescence localization and flow cytometry was used to test the collagen phygocytosis of hPDLF stimulated by the various concentration of LPS for 48 hours in vitro.
RESULTS: The collagen phygocytosis of hPDLF was increased significantly by 0.1 microg/mL LPS (P < 0.05).
CONCLUSION: This study indicates that P. gingivalis LPS may enhance the degradation of collagen by stimulating the phagocytic activity of the hPDLF in periodontitis.