International urology and nephrology · 2022
The effect of intraurethral hyaluronic acid on healing and fibrosis in rats with experimentally induced urethral trauma.
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Doğantekin Engin, Akgül Turgay, Eser Eylem Pınar, Kotanoğlu Mustafa, Bayburtluoğlu Veysel, Hücümenoğlu Sema
Аннотация
PURPOSE: To assess the efficacy of hyaluronic acid (HA) application after urethral trauma for preventing spongiofibrosis and inflammation in the early period.
METHODS: A total of twenty-four rats were divided into 3 groups, with 8 rats in each. The urethra was traumatized with a 24 G needle sheath in all rats. Group 1 of rats were applied 0.9% saline solution twice a day, Group 2 were applied 0.9% saline solution and sodium HA 1% once a day, Group 3 were applied 1.0% HA twice a day. After 21 days, penectomy was performed in all rats. Inflammation, spongiofibrosis, hyperemia and edema in the urethra were investigated for each group.
RESULTS: Histopathologic analysis revealed less fibrosis in both group 2 and group 3 compared to Group 1 (p = 0.004). There were no statistically significant differences among the groups in terms of inflammation, hyperemia, edema and congestion (p = 0.563, p = 0.069, p = 0.069, p = 0.068, respectively). Severe fibrosis was observed in 6 (75%) rats in Group 1, and in none of the rats of Group 2 or Group 3. With respect to spongiofibrosis compared to the control group, both Group 2 and Group 3 have statistically significant differences (p = 0.004). Moderate spongiofibrosis was observed in 5 (62.5%) rats in Group 2 and in 3 (37.5%) rats in Group 3. Statistically, there were no significant differences in respect of severity between Group 2 and Group 3 (p = 0.014).
CONCLUSION: Intraurethral HA application after urethral trauma can decrease spongiofibrosis.
METHODS: A total of twenty-four rats were divided into 3 groups, with 8 rats in each. The urethra was traumatized with a 24 G needle sheath in all rats. Group 1 of rats were applied 0.9% saline solution twice a day, Group 2 were applied 0.9% saline solution and sodium HA 1% once a day, Group 3 were applied 1.0% HA twice a day. After 21 days, penectomy was performed in all rats. Inflammation, spongiofibrosis, hyperemia and edema in the urethra were investigated for each group.
RESULTS: Histopathologic analysis revealed less fibrosis in both group 2 and group 3 compared to Group 1 (p = 0.004). There were no statistically significant differences among the groups in terms of inflammation, hyperemia, edema and congestion (p = 0.563, p = 0.069, p = 0.069, p = 0.068, respectively). Severe fibrosis was observed in 6 (75%) rats in Group 1, and in none of the rats of Group 2 or Group 3. With respect to spongiofibrosis compared to the control group, both Group 2 and Group 3 have statistically significant differences (p = 0.004). Moderate spongiofibrosis was observed in 5 (62.5%) rats in Group 2 and in 3 (37.5%) rats in Group 3. Statistically, there were no significant differences in respect of severity between Group 2 and Group 3 (p = 0.014).
CONCLUSION: Intraurethral HA application after urethral trauma can decrease spongiofibrosis.