Scientific reports · 2025
COVID-19 and neuropathy in type 2 diabetes.
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Ponirakis Georgios, Al-Janahi Ibrahim, Elgassim Einas, Al Obaidan Aisha, Gad Hoda, Petropoulos Ioannis N, Khan Adnan, Zaghloul Hadeel B, Ali Hamda, Siddique Mashhood A, Mohamed Fatima F S, Ahmed Lina H M, Dakroury Youssra, El Shewehy Abeer M M, Al-Thani Shaikha N, Ahmed Farheen, Hussein Rawan, Mahmoud Salah, Salivon Iuliia, Homssi Moayad, Hadid Nebras H, Ali Ateeque Mohamed, Khan Safah, Mahfoud Ziyad R, Zirie Mahmoud A, Bitirgen Gulfidan, Al-Ansari Yousuf, Alhatou Mohammed I, Atkin Stephen L, Malik Rayaz A
Аннотация
This study investigated the risk factors for COVID-19 and its impact on diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes (T2D). Patients with T2D underwent assessments with the NICE post-COVID questionnaire, DN4 questionnaire, vibration perception threshold (VPT), and corneal confocal microscopy (CCM) before and 11.0 ± 8.9 months after developing COVID-19. Of 76 participants with T2D, 35 (46.1%) developed COVID-19, of whom 8 (22.9%) developed severe COVID-19 and 9 (25.7%) developed long-COVID. The development of COVID-19 was associated with lower systolic blood pressure (P < 0.05). The presence and severity of DPN were not associated with developing COVID-19, severe COVID-19, or long-COVID (P = 0.42-0.94). Women were eight times more likely to develop long-COVID (P < 0.05) and elevated body weight, LDL, and VPT were associated with the development of long-COVID (P < 0.05 - 0.01). The long-COVID group exhibited significant changes in triglycerides and LDL (P < 0.05 for both) and body weight (P < 0.01) at follow-up. Their impact on clinical and neuropathy measures was comparable in patients with and without COVID-19 (P = 0.08-0.99). There was a significant reduction in corneal nerve measures (P < 0.05-0.0001) in patients with and without COVID-19. A low systolic blood pressure, altered lipids, body weight, higher VPT, and gender may determine the impact of COVID-19 in patients with T2D, but there was no evidence of an impact of COVID-19 on the development or progression of DPN.