Critical role of the inflammatory rheostat in influenza-associated pulmonary aspergillosis.

Respiratory infections due to influenza A virus remain a major cause of morbidity and mortality. In the past decade, influenza-associated pulmonary aspergillosis (IAPA) has emerged as a major clinical issue. However, the mechanisms involved in linking host-virus-fungal interactions remain poorly understood. Increasing experimental and clinical evidence is converging to underline the impact of inflammatory imbalance in the pathogenesis of IAPA.