Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2004
[Effect of helicobacter pylori on gastric mucosal cell proliferation in gastritis].
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Liu Zheng-xin, Chen Bao-wen, Yang Gui-bin, Zhang Xi-quan, Jia Bo-qi
Аннотация
OBJECTIVE: To study the effect of helicobacter pylori on gastric mucosal cell proliferation in gastritis.
METHODS: Fifty-six gastritis patients with or without Helicobacter pylori infection (Hp+ 27; Hp- 29) were selected. The expression of proliferation cell nuclear antigen (PCNA), epidermal growth factor receptor (EGFR), transforming growth factor beta receptor type I and type II(TGFbetaRI, TGFbetaRII) in gastric mucosa were examined by immunohistochemical method.
RESULTS: The PCNA and EGFR were significantly higher in Hp positive chronic gastritis patients than in Hp negative ones(P<0.05); The TGFbetaRI(P=0.16) and TGFbetaRII(P=0.97) were lower.
CONCLUSION: Hp infection promotes over proliferation of gastric mucosal cells.
METHODS: Fifty-six gastritis patients with or without Helicobacter pylori infection (Hp+ 27; Hp- 29) were selected. The expression of proliferation cell nuclear antigen (PCNA), epidermal growth factor receptor (EGFR), transforming growth factor beta receptor type I and type II(TGFbetaRI, TGFbetaRII) in gastric mucosa were examined by immunohistochemical method.
RESULTS: The PCNA and EGFR were significantly higher in Hp positive chronic gastritis patients than in Hp negative ones(P<0.05); The TGFbetaRI(P=0.16) and TGFbetaRII(P=0.97) were lower.
CONCLUSION: Hp infection promotes over proliferation of gastric mucosal cells.
Предметные рубрики MeSH
Activin Receptors, Type IAdultAgedCell DivisionErbB ReceptorsFemaleGastric MucosaGastritisHelicobacter InfectionsHelicobacter pyloriHumansMaleMiddle AgedProliferating Cell Nuclear AntigenProtein Serine-Threonine KinasesReceptor, Transforming Growth Factor-beta Type IReceptor, Transforming Growth Factor-beta Type IIReceptors, Transforming Growth Factor beta