Markers for predicting the severity of acute pancreatitis.

OBJECTIVE

Aim: To identify markers for predicting the severity of acute pancreatitis and the possible development of pancreatic necrosis.

PATIENTS AND

METHODS

Materials and

Methods

Prospective analysis of 81 patients with moderate and severe acute pancreatitis while performing correlation analysis, building a logistic regression model.

RESULTS

Results

A direct correlation of medium strength between sFGL2 and the following parameters was found D-dimer (R=0.47 (p<0.001)), C-reactive protein (R=0.3 (p=0.03)), intra-abdominal pressure (R=0.54 (p<0.0001)). It was discovered that such indicators as: BISAP score (OR=1.62 95%CI 0.99-2.66) p=0.05, sFGL2 (OR=1.01 95%CI 1.0-1.05) p=0.007, CRP (OR=1.01 95%CI 1.0-1.01) p=0.02, D-dimer (OR=2.59 95%CI 1.57-4.26) p=0.0002, intra-abdominal pressure (OR=195 95%CI 1, 39-2.72) p=0.0001 allow to predict the progression of necrotic changes in the pancreatic tissue and retroperitoneal space. And such indicators as: BISAP scale (OR=2.19 95%CI 1.33-3.59) p=0.002, sFGL2 (OR=1.01 95%CI 1.0-1.1) p=0.0002, CRP (OR=1.02 95%CI 1.01-1.02) p<0.0001, D-dimer (OR=1.99 95%CI 1.4-2.83) p=0.0001, intra-abdominal pressure (OR=2.36 95%CI 1.59-3.5) p<0.0001) may play a role in predicting worsening of acute pancreatitis.

CONCLUSION

Conclusions

It has been revealed that elevated levels of sFGL2, D-dimer and intra-abdominal pressure can predict the progression of necrotic changes in the pancreatic tissue and retroperitoneal space. And such indicators as the BISAP score, sFGL2, CRP, D-dimer and intra-abdominal pressure may play a role in predicting the deterioration of acute pancreatitis.