Internal medicine (Tokyo, Japan) · 2020
Synchronously Multiple Gastric Adenocarcinomas with Intestinal Mucin Phenotype in a Patient not Infected with Helicobacter pylori, Showing a Gastritis-like Appearance.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Kishimoto Kenichi, Shibagaki Kotaro, Itawaki Ayako, Tanaka Shinsaku, Takahashi Yusuke, Cho Yumi, Ikuta Yukihiro, Oshima Naoki, Nagasaki Makoto, Ishihara Shunji
Аннотация
Helicobacter pylori (H. pylori)-negative gastric cancer (HPNGC) usually shows a gastric mucin phenotype, but there are a few case reports of HPNGC with an intestinal mucin phenotype. We herein report a case of multiple HPNGC with an intestinal mucin phenotype showing a gastritis-like appearance. A 68-year-old H. pylori-uninfected man was suspected of having antral gastritis on endoscopy, but a histologic examination revealed multiple well-differentiated adenocarcinomas with positive-CDX2/MUC2/CD10 and negative-MUC5AC/MUC6. P53 was overexpressed, and intestinal metaplasia was sporadically detected in the non-atrophic mucosal background, thus indicating H. pylori-unrelated multistage carcinogenesis. The neoplastic surfaces were covered by a non-neoplastic epithelium, which caused a gastritis-like appearance. This report suggested the possibility of overlooking this neoplasm.