Impact of bariatric surgery on serum C5a levels: A prospective study.

C5a, a key complement pathway component, is produced in adipose tissue and promotes inflammation linked to atherosclerosis. It also influences lipid and glucose metabolism, suggesting a role in obesity-related dysfunction. This study measured by ELISA serum C5a levels in individuals with obesity before and after Roux-en-Y gastric bypass. Pre-surgery, the median C5a level was 12.0 ng/mL (IQR: 7.0-18.0); post-surgery, it dropped to 6.3 ng/mL (IQR: 4.4-8.9; p = 0.0002). However, no significant correlations were found between C5a changes and lipid or glycemic profiles.