Significant progress in hereditary gastrointestinal cancer research presented at the meeting of the International Society for Gastrointestinal Hereditary Tumors (InSiGHT) 10th meeting of InSiGHT, June 19th -22nd, 2024, Barcelona, Spain.

The 2024 Biennal Meeting of the International Society for Gastrointestinal Hereditary Tumors (InSiGHT) was held in Barcelona from June 19th to 22nd. The meeting featured a diverse program, including lectures, abstract presentations, flash talks, debates and poster presentations. Over 400 attendants from various countries participated. The primary focus of the program was on Lynch syndrome and polyposis syndromes. Other conditions addressed included constitutional mismatch repair deficiency (CMMRD), hereditary pancreatic cancer, hereditary gastric cancer, early-onset colorectal cancer, and familial colorectal cancer. This personal report summarizes a selection of lectures and debates, highlighting the progress made in the understanding of each hereditary cancer syndrome and its related conditions.