Transplantation proceedings · 2012
Survival of cystic fibrosis patients undergoing liver and liver-lung transplantations.
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Desai C S, Gruessner A, Habib S, Gruessner R, Khan K M
Аннотация
BACKGROUND: We evaluated the outcome of combined liver-lung transplantation (L-LTx) in cystic fibrosis (CF) patients with liver transplantation (LTx) for CF liver disease.
METHODS: The United Network for Organ Sharing (UNOS) data were analyzed from October 1987 to August 2009.
RESULTS: Of 294 patients (210 children), 265 (90.1%) received an LTx and 29, an L-LTx. Patient survival was: adult LTx, 80%, 74%, and 67% at 1, 3, and 5 years, and L-LTx, 72%, 61.4%, and 61.4% (P = .7); pediatric LTx, 85%, 82%, and 74% at 1, 3, and 5 years, and L-LTx, 83%, 83%, and 83% (P = .4). Pediatric patients had a slight survival advantage over adults for LTx (P = .08). Graft survival, not affected by immunosuppression regimens, was similar to patient survival.
CONCLUSIONS: The outcome of L-LTx appears similar to LTx in CF providing support for the prospect of a combined transplant.
METHODS: The United Network for Organ Sharing (UNOS) data were analyzed from October 1987 to August 2009.
RESULTS: Of 294 patients (210 children), 265 (90.1%) received an LTx and 29, an L-LTx. Patient survival was: adult LTx, 80%, 74%, and 67% at 1, 3, and 5 years, and L-LTx, 72%, 61.4%, and 61.4% (P = .7); pediatric LTx, 85%, 82%, and 74% at 1, 3, and 5 years, and L-LTx, 83%, 83%, and 83% (P = .4). Pediatric patients had a slight survival advantage over adults for LTx (P = .08). Graft survival, not affected by immunosuppression regimens, was similar to patient survival.
CONCLUSIONS: The outcome of L-LTx appears similar to LTx in CF providing support for the prospect of a combined transplant.