Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2010
[Correlation study on polymorphisms of vitamin D receptor gene in patients with periodontitis].
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Zhang Li, Meng Huan-xin, Zhao Hong-shan, Li Qi-yan, Xu Li, Chen Zhi-bin, Shi Dong, Feng Xiang-hui
Аннотация
OBJECTIVE: To investigate the relationship between vitamin D receptor (VDR) gene polymorphisms and periodontitis.
METHODS: Ninety patients with aggressive periodontitis(AgP), 34 patients with chronic periodontitis and 91 healthy controls were recruited in this study. VDR gene was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) with Taq I restriction endonuclease.
RESULTS: The detection frequency of Tt genotype was higher in the aggressive periodontitis patients than in the healthy controls (16.7% vs 7.7%, P>0.05). The difference between the female aggressive periodontitis patients and healthy controls (20.8% vs 4.2%, P<0.05) was statistically significant, but no difference was found between the male patients and controls (10.8% vs 11.6%, P>0.05). There was a strong association between aggressive periodontitis and Tt genotype in females (AgP patients vs healthy controls, OR=6.02). The detection frequency of Taq I ER-alpha genotypes was not statistically different between the chronic periodontitis patients and healthy controls.
CONCLUSION: In female Han Chinese population, the Tt VDR genotype may be associated with aggressive periodontitis.
METHODS: Ninety patients with aggressive periodontitis(AgP), 34 patients with chronic periodontitis and 91 healthy controls were recruited in this study. VDR gene was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) with Taq I restriction endonuclease.
RESULTS: The detection frequency of Tt genotype was higher in the aggressive periodontitis patients than in the healthy controls (16.7% vs 7.7%, P>0.05). The difference between the female aggressive periodontitis patients and healthy controls (20.8% vs 4.2%, P<0.05) was statistically significant, but no difference was found between the male patients and controls (10.8% vs 11.6%, P>0.05). There was a strong association between aggressive periodontitis and Tt genotype in females (AgP patients vs healthy controls, OR=6.02). The detection frequency of Taq I ER-alpha genotypes was not statistically different between the chronic periodontitis patients and healthy controls.
CONCLUSION: In female Han Chinese population, the Tt VDR genotype may be associated with aggressive periodontitis.