Influences of Coagulant Polarity on the Modulus of the Chitin Hydrogel.

The chitin hydrogel draws great attention in biomedical fields owing to its high similarity and good affinity for peptides. The conversion of raw chitin to the designed hydrogel through a sol-gel process prevails, while the modulus of the chitin hydrogel is significantly influenced by the factors of gelation technology (i.e., coagulation, involving polymer chain rearrangement and the reconstruction of multiple interactions). Water and several organic solvents such as ethanol, DMAc, and DMSO are effective coagulants for aqueous chitin/KOH/urea solutions. In particular, the concentration of aqueous ethanol solutions displays a high dependency on the modulus of chitin hydrogels. However, recent reports about chitin hydrogel fabrication seldom demonstrate the effect of coagulant factors on hydrogel performance. Our study found that the polarity of the coagulant and its diffusion index for entry into the chitin solution during the coagulation process had a direct influence on the hydrogel modulus. The influence of the two factors was investigated to find out their quantified relationship with the hydrogel modulus, which will inspire a practical method to develop new coagulants to prepare modulus-manipulable chitin hydrogels.