BMC pulmonary medicine · 2026
Impact of CPAP and ventilator system resistance on respiratory effort in healthy volunteers.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Lindner Simon, Doerflinger Lena, Drotleff Luisa S, Link Burcu, Neetz Benjamin, Michels-Zetsche Julia D, Herth Felix J F, Duerschmied Daniel, Britsch Simone
Аннотация
INTRODUCTION: Continuous positive airway pressure (CPAP) is widely used for the treatment of acute and chronic respiratory failure and inspiratory support pressure (ΔPinsp) can be added to achieve non-invasive ventilation (NIV). We performed a physiological study to determine the effect of CPAP and inspiratory support pressure on respiratory effort measured by esophageal tidal swings in healthy volunteers.
METHODS: Esophageal tidal swings were measured in spontaneously breathing, healthy volunteers undergoing 4 airway pressure conditions: atmospheric pressure (A), on a ventilator without any applied pressures (V), CPAP of 5 cmH2O, and NIV with PEEP of 5 cmH2O and ΔPinsp of 5 cmH2O during rest, light, and strenuous exercise. The sequence of airway conditions was randomized and the investigator reading the esophageal pressures was blinded.
RESULTS: Thirty-eight individuals were included in the analysis. Esophageal tidal swing during rest was highest when CPAP was applied, compared to A and NIV. During light and strenuous exercise, both V and CPAP increased respiratory effort, compared to A and NIV, suggesting an increase in ventilator system resistance at higher minute ventilation.
CONCLUSION: CPAP increased respiratory effort compared to both NIV and breathing at atmospheric pressure, but ventilator system resistance appeared to be a more relevant determinant of respiratory effort at higher minute ventilation induced by exercise. As acute respiratory failure often is associated with high minute ventilation, further studies are needed to examine the potential clinical implications of these findings.
METHODS: Esophageal tidal swings were measured in spontaneously breathing, healthy volunteers undergoing 4 airway pressure conditions: atmospheric pressure (A), on a ventilator without any applied pressures (V), CPAP of 5 cmH2O, and NIV with PEEP of 5 cmH2O and ΔPinsp of 5 cmH2O during rest, light, and strenuous exercise. The sequence of airway conditions was randomized and the investigator reading the esophageal pressures was blinded.
RESULTS: Thirty-eight individuals were included in the analysis. Esophageal tidal swing during rest was highest when CPAP was applied, compared to A and NIV. During light and strenuous exercise, both V and CPAP increased respiratory effort, compared to A and NIV, suggesting an increase in ventilator system resistance at higher minute ventilation.
CONCLUSION: CPAP increased respiratory effort compared to both NIV and breathing at atmospheric pressure, but ventilator system resistance appeared to be a more relevant determinant of respiratory effort at higher minute ventilation induced by exercise. As acute respiratory failure often is associated with high minute ventilation, further studies are needed to examine the potential clinical implications of these findings.