Preeminent Terminator of Oxygen Free Radicals─Mineralized Reduced Water.

Drinking water is an essential daily intake to hydrate the body. It is conceivable that water, when endowed with antioxidant properties, will be the most natural radical terminator surpassing conventional pill-based or food-derived antioxidants. However, current end-of-pipe purification of municipal water generally depletes minerals pivotal for antioxidant potency. To surmount this dilemma, we assemble a multistage and multifunctional water treatment system using various filter materials that dislodge contaminants, mineralize water and impart reductive attributes. The mineralized reduced water (MRW) generated by this system possesses an ideal antioxidant water quality with weak alkalinity, negative oxidation-reduction potential and rich minerals including calcium, magnesium, zinc and silicon. This water decreases oxidative products in vivo via counteracting reactive oxygen species and activating the endogenous antioxidant system governed by nuclear factor erythroid 2-related factor 2. Moreover, long-term intake of MRW effectively retards xenografted tumor growth without any discernible hematologic and organic toxicity. These findings portend enormous promise for MRW in the prevention and treatment of oxidative stress-related maladies and even antiaging.