Curdlan/xanthan gum-based composite hydrogel with near-infrared irradiation responsive properties for infected wounds healing.

Open wounds are prone to bacterial contamination and delayed healing due to environmental exposure, necessitating the development of advanced wound dressings. Hydrogels are ideal candidates for wound care for maintaining a moist environment which benefits for the cell migration and tissue regeneration. However, conventional polysaccharide hydrogels lack intrinsic antibacterial properties, prompting the incorporation of antibacterial agents. Herein, we present a novel composite hydrogel synthesized from curdlan (CUR) and xanthan gum (XG) via thermal annealing, augmented with MXene and Mg2+ to enhance antibacterial efficacy and promote cellular migration. The results proved that the mechanical properties of the composite hydrogel prepared with CUR and XG are significantly enhanced. Due to the influence of near-infrared irradiation, the antibacterial rates of XC/Mg2+/MX against S. aureus and P. aeruginosa are 81.84 % and 89.27 %, respectively. This innovative composite hydrogel offers new insights and avenues in the progress of sophisticated wound healing dressings areas.