The International journal of artificial organs · 1999
Femoral catheters: safety and efficacy in peripheral blood stem cell collection.
Клиническое исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Adorno G, Zinno F, Bruno A, Lanti A, Ballatore G, Masi M, Cudillo L, Del Poeta G, Riccitelli A, Del Principe M I, Pepe R, Marchitelli E, Morosetti M, Meloni C, Isacchi G, Amadori S
Аннотация
Central venous access is necessary in patients candidate for peripheral blood stem cell (PBSC) collection. We report our experience with a dual lumen femoral catheter (Gamcath, 11 french), initially designed for hemodialysis. We studied 147 patients and performed 488 collections after mobilization with either G-CSF alone or chemotherapy + G-CSF, when the white blood cell count exceeded 1 x 10(9)/L, or when a measurable population of CD34+ cells (20/microL) was detected in peripheral blood. All patients received systemic anticoagulation with a low weight heparin and ultrasound examination was performed after the removal of the catheter. Seven patients developed thrombosis (4.7%), ten experienced hematomas at the site of catheter placement (6.8%) despite prophylactic platelet transfusions, while only one patient (0.6%) had a catheter-related infection. In conclusion, the short-term use of large bore femoral catheters in setting up PBSC collection seems to be associated with minimal risk of infection and low thrombotic incidence.