Assessment and Comparison of Cyclin D1 Expression in Different Histopathological Grades of Oral Epithelial Dysplasia - An In vitro Study.

AIM AND

OBJECTIVES

Quantitative evaluation and comparison of Cyclin D1 expression in various histological grades of oral epithelial dysplasia.

MATERIAL AND

METHODS

A total of 66 instances of oral epithelial dysplasia were included, with a histological diagnosis, consisting of 22 cases for each of the three histopathological grades. These cases were evaluated for cyclin D1 expression using immunohistochemistry techniques. To compare the average number of positive cells among the three groups with epithelial dysplasia, the Tukey's multiple post hoc method and the one-way ANOVA test were utilized. A P value of 0.05 or less was considered statistically significant.

RESULTS

The expression of Cyclin D1 protein has been shown to vary significantly across mild, moderate, and severe epithelial dysplasia, with the group exhibiting severe oral epithelial dysplasia (OED) showing the highest average levels of expression.

CONCLUSION

The overproduction of cyclin D1 in individuals with severe epithelial dysplasia suggests that it could serve as a precursor to the onset of oral cancer. Cyclin D1 may act as a potential predictive marker for malignant transformation.