[The characteristics of the lipid peroxidation and antioxidant activity of the duodenal mucosa in peptic ulcer patients].

AIM: Lipid peroxidation (LPO) and antioxidant defense (AOD) in ulcer and periulcer zones of duodenal mucosa were studied at different phases of ulcer.

MATERIALS AND

METHODS

111 patients with duodenal ulcer exacerbation before treatment and in the course of the treatment were studied versus 23 healthy volunteers.

RESULTS

In active ulcer there was high activity of LPO and depressed AOD. LPO may be initiated by Helicobacter pylori. Pathogenetic measures including anti-Helicobacter ones decreased LPO hyperactivity and promoted AOD normalization.

CONCLUSION

In ulcer, optimal treatment is supposed to combine antisecretory and antibacterial drugs adjusted to the activity of ulcer and imbalance between LPO and AOD systems in gastric and duodenal mucosa.