Медицинская библиотека · Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine · 2001

[Experimental study of inhibitory effect of kangxian recipe on TGF-beta 1 induced hepatocyte apoptosis].

Zhang L H, Wu J G, Yao H P

Аннотация на английскомСтатьяПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

OBJECTIVE

To study the inhibitory effect of Kangxian Recipe (KXR) on TGF-beta 1 induced hepatocyte apoptosis.

METHODS

The in vitro model of hepatocyte apoptosis was established by cell biologic methods, utilizing the characteristics of TGF-beta 1 to observe the inhibitory effect of KXR on hepatocyte apoptosis.

RESULTS

TGF-beta 1 induced apoptosis of hepatocyte in a dose-dependent manner. The apoptosis rate of 2.2.15 cells was 63% when 500 ng/L TGF-beta 1 was used, while for HepG2 cell, it was merely 44%. After treatment of 20 ng/L KXR, the apoptosis rate of the two kinds of cell lines lowered to 33% and 24% respectively. The inhibition rate of both groups was about 50%.

CONCLUSION

KXR had strong inhibitory effect on hepatocyte apoptosis induced by TGF-beta 1.

Для цитирования: Zhang L H, Wu J G, Yao H P. [Experimental study of inhibitory effect of kangxian recipe on TGF-beta 1 induced hepatocyte apoptosis].. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2001.

Предметные рубрики MeSH

Apoptosis Drug Combinations Drugs, Chinese Herbal Hepatitis B Hepatoblastoma Hepatocytes Humans Liver Neoplasms Transforming Growth Factor beta Tumor Cells, Cultured

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