[Risk factors of postoperative complications of pancreatoduodenectomy].

BACKGROUND &

OBJECTIVE

Pancreatoduodenectomy is the main treatment for pancreatic carcinoma and periampullary carcinoma. This study was to explore risk factors of postoperative complications of pancreatoduodenectomy for pancreatic carcinoma and periampullary carcinoma.

METHODS

Clinical data of 94 patients with pancreatic carcinoma or periampullary carcinoma, underwent pancreatoduodenectomy at the second affiliated hospital of Guangzhou Medical Collage and Gansu Provincial Tumor Hospital from Jan. 1993 to Nov. 2006, were analyzed. Thirteen clinicopathologic factors that could possibly influence postoperative mortality and morbidity were selected for univariate analysis and multivariate analysis using Cox proportional hazards model.

RESULTS

Univariate analysis showed that major risk factors of postoperative mortality and morbidity of the patients were total serum bilirubin level, serum album level, duration of jaundice, decompression of jaundice, operating time, intra-operative bleeding, and depth of tumor invasion (P<0.05). Multivariate analysis showed that intra-operative bleeding, operating time, total serum bilirubin level, and duration of jaundice were independent risk factors (P<0.01).

CONCLUSION

Postoperative mortality and morbidity of pancreatoduodenectomy for periampullary carcinoma are closely related to intra-operative bleeding, operating time, serum bilirubin level and duration of jaundice.