Toxicology in vitro : an international journal published in association with BIBRA · 2023
m-Cresol,a pesticide intermediate, induces hepatotoxicity and behavioral abnormalities in zebrafish larvae through oxidative stress, apoptosis.
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Wang Ying, Wu Jie, Wan Mengqi, Yang Dou, Liu Fasheng, Li Kehao, Hu Manxin, Tang Yuanyuan, Lu Huiqiang, Zhang Shouhua, Xiong Yuanzhen
Аннотация
m-Cresol is mainly used as a pesticide intermediate. It is industrially used in the production of insecticides including boronone and fenthion. It is also an intermediate for color film, resins, plasticizers and fragrances. However, m-cresol has the potential to cause environmental contamination if released accidentally. The molecular mechanism of m-cresol mediated hepatotoxicity remains unclear. In this study, zebrafish larvae were used to comprehensively study the hepatotoxicity of m-cresol and explore its molecular mechanism. After 72 hpf of fertilization, zebrafish larvae were exposed to 0.2 mM,0.4 mM, and 0.6 mM of m-cresol. Varying degrees of liver injury and behavioral abnormalities were observed. The hepatotoxicity of zebrafish larvae may be induced by oxidative stress pathway and apoptosis of cell.