Tissue antigens · 1981
Histocompatibility determinants in Israeli Jewish patients with coeliac disease: population and family study.
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Brautbar C, Freier S, Ashkenazi A, Dekelbaum R, Tur-Kaspa I, Amar A, Cohen I, Sharon R, Abecassis R, Levene C, Cohen T, Albert E
Аннотация
The association between HLA and coeliac disease (CD) was studied in the Jewish population of Israel. A total of 112 patients were typed for HLA-A,B,C antigens, including 67 patients whose families were typed in order to deduce the genotypes. Forty-seven patients were typed for HLA-DR antigens. The HLA-A,B,C data show a pattern of association, which is similar to that found in European CD patients: HLA-B8 is increased, although to a lower degree; a suggestive, insignificant increase for Aw30, B13 and Cw6 and a decrease of Bw35 were noted. The DR antigens DR3 and DR7 are associated with CD in the Jewish population. An excess of DR3/DR7 heterozygotes was noted. The data from family and population studies support a model in which two different HLA-DR associated genes are interacting.