Oncogenicity and Therapeutic Implications of Molecular Biomarkers in Colorectal Carcinoma.

Colorectal carcinoma (CRC) is the most prevalent malignancy of the gastrointestinal tract and remains a leading cause of cancer-related illness and death worldwide. Recently, new treatment strategies have emerged with the identification of important biomarkers in CRC. As the emphasis on precision medicine in oncology intensifies, testing tumor specimens for key genomic alterations is becoming standard-of-care. This article seeks review the key molecular changes in CRC with important therapeutic implications.