[THE STRUCTURE OF THE ILEUM AFTER THE RESECTION OF LIVER PARENCHYMA].

The ileum was morphologically examined in 45 sexually mature white male rats, which were divided into 3 groups: I group included 15 intact animals, II - 15 rats, in which 31.5% of the liver parenchyma was removed, III - 15 animals after resection 58,1% of liver parenchyma. Euthanasia of rats was performed by bloodletting under the conditions of thiopental anesthesia 1 month after the beginning of the experiment. Histological micropreparations were made from the ileum, which were studied morphometrically. Quantitative indicators were processed statistically. It was revealed that after resection of 31.5% of the parenchyma of the liver, the morphometric parameters studied were insignificantly altered. Resection of 58.1% of the liver parenchyma lead to postresectional portal hypertension, which was characterized by venous full-blood in the veins of the portal hepatic vein system and morphological changes in the ileum. Venous thrombosis, edema, dystrophic, necrotic, infiltrative, sclerotic and atrophic processes were observed in the investigated organ. The relative volume of the damaged epitheliocytes of the mucous membrane of the ileum reached 64.50±0.72%, and myocytes in the muscular membrane - 41.10±0.54%. The pronounced changes in nuclear-cytoplasmic relations in epitheliocytes and stromal-myocytic muscle tissue testified to violations of tissue and cellular structural homeostasis. Thus, the removal of large volumes of liver parenchyma leads to postresectional portal hypertension expressed by remodeling of the structures of the ileum, which is characterized by uneven disproportional changes in the spatial characteristics of the organ structures, disturbances between them, vascular disorders, edema, dystrophic, necrobiotic changes in epitheliocytes, endothelial cells, myocytes, stromal elements, infiltrative, sclerotic and atrophic processes.