Медицинская библиотека · Head & neck · 2014

Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke.

Li Ryan, Faden Daniel L, Fakhry Carole, Langelier Chaz, Jiao Yuchen, Wang Yuxuan, Wilkerson Matthew D, Pedamallu Chandra Sekhar, Old Matthew, Lang James, Loyo Myriam, Ahn Sun Mi, Tan Marietta, Gooi Zhen, Chan Jason, Richmon Jeremy, Wood Laura D, Hruban Ralph H, Bishop Justin, Westra William H, Chung Christine H, Califano Joseph, Gourin Christine G, Bettegowda Chetan, Meyerson Matthew, Papadopoulos Nickolas, Kinzler Kenneth W, Vogelstein Bert, DeRisi Joseph L, Koch Wayne M, Agrawal Nishant

Сравнительное исследованиеСтатьяМногоцентровое исследованиеПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

BACKGROUND

Evidence suggests the incidence of oral tongue squamous cell carcinoma is increasing in young patients, many who have no history of tobacco use.

METHODS

We clinically reviewed 89 patients with oral tongue cancer. Exomic sequencing of tumor DNA from 6 nonsmokers was performed and compared to previously sequenced cases. RNA from 20 tumors was evaluated by massively parallel sequencing to search for potentially oncogenic viruses.

RESULTS

Non-smokers (53 of 89) were younger than smokers (36 of 89; mean, 50.4 vs 61.9 years; p < .001), and seemed more likely to be women (58.5% vs 38.9%; p = .069). Nonsmokers had fewer TP53 mutations (p = .02) than smokers. No tumor-associated viruses were detected.

CONCLUSION

The young age of nonsmoking patients with oral tongue cancer and fewer TP53 mutations suggest a viral role in this disease. Our efforts to identify such a virus were unsuccessful. Further studies are warranted to elucidate the drivers of carcinogenesis in these patients.

Для цитирования: Li Ryan, Faden Daniel L, Fakhry Carole, Langelier Chaz, Jiao Yuchen, Wang Yuxuan, Wilkerson Matthew D, Pedamallu Chandra Sekhar, Old Matthew, Lang James, Loyo Myriam, Ahn Sun Mi, Tan Marietta, Gooi Zhen, Chan Jason, Richmon Jeremy, Wood Laura D, Hruban Ralph H, Bishop Justin, Westra William H, Chung Christine H, Califano Joseph, Gourin Christine G, Bettegowda Chetan, Meyerson Matthew, Papadopoulos Nickolas, Kinzler Kenneth W, Vogelstein Bert, DeRisi Joseph L, Koch Wayne M, Agrawal Nishant. Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke.. Head & neck. 2014. DOI: 10.1002/hed.23807.

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