Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
Apigenin mitigates oxidative stress, neuroinflammation, and cognitive impairment but enhances learning and memory in aluminum chloride-induced neurotoxicity in rats.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Oyagbemi Ademola Adetokunbo, Femi-Akinlosotu Omowumi Moromoke, Obasa Adedunsola Adewunmi, Ojo Moses Semilore, Salami Adeola Temitope, Ajibade Temitayo Olabisi, Onukak Charles Etang, Igado Olumayowa Olawumi, Esan Oluwaseun Olarenwaju, Oyagbemi Taiwo Olaide, Adeogun Adewumi Victoria, Awoyomi Omolola Victoria, Ikokide Joseph E, Jaja Ishmael Festus, Ola-Davies Olufunke Eunice, Omobowale Temidayo Olutayo, Saba Adebowale Bernard, Oguntibeju Oluwafemi Omoniyi, Nwulia Evaristus, Yakubu Momoh Audu
Аннотация
INTRODUCTION: Aluminum chloride (AlCl3) exposure has been linked to neurotoxicity in various animal models, presenting significant concern to human health due to its potential implications in neurodegenerative diseases. Aluminum chloride is a widely recognized neurotoxin and has been used as an animal model of Alzheimer's disease via mechanisms linked with oxidative stress and inflammation. The study investigated the potential ameliorative effect of apigenin on AlCl3-induced neurotoxicity in rats.
METHODS: Forty adult male Wistar rats were randomly divided into four different groups - control, AlCl3 (100 mg/kg), apigenin (50 mg/kg) plus AlCl3, and apigenin (50 mg/kg) alone administered orally for 14 days.
RESULTS: Our findings revealed AlCl3 exposure induced significant neurobehavioral deficits, oxidative stress, neuroinflammation, and loss of the Purkinje cell layer of the cerebellum. Treatment with apigenin attenuated neuroinflammation and enhanced learning and memory with significant improvement in recognition index.
DISCUSSION: Apigenin demonstrates promising ameliorative effects against AlCl3-induced neurotoxicity in rats.
HIGHLIGHTS: Aluminum chloride toxicity caused significant reduction in learning, exploration, and memory. Aluminum chloride toxicity induced neurotoxicity, increased biomarkers of oxidative stress, neuroinflammation, and precipitated cognitive impairment. Apigenin improved brain antioxidant, enhanced learning, exploration, and memory.
METHODS: Forty adult male Wistar rats were randomly divided into four different groups - control, AlCl3 (100 mg/kg), apigenin (50 mg/kg) plus AlCl3, and apigenin (50 mg/kg) alone administered orally for 14 days.
RESULTS: Our findings revealed AlCl3 exposure induced significant neurobehavioral deficits, oxidative stress, neuroinflammation, and loss of the Purkinje cell layer of the cerebellum. Treatment with apigenin attenuated neuroinflammation and enhanced learning and memory with significant improvement in recognition index.
DISCUSSION: Apigenin demonstrates promising ameliorative effects against AlCl3-induced neurotoxicity in rats.
HIGHLIGHTS: Aluminum chloride toxicity caused significant reduction in learning, exploration, and memory. Aluminum chloride toxicity induced neurotoxicity, increased biomarkers of oxidative stress, neuroinflammation, and precipitated cognitive impairment. Apigenin improved brain antioxidant, enhanced learning, exploration, and memory.