Reduced Functional Connectivity in Nucleus Accumbens Subregions Associates With Cognitive Changes in Alzheimer's Disease.

BACKGROUND AND PURPOSE: The nucleus accumbens (NAc), an important component of the reward circuit, is believed to play an indispensable role in Alzheimer's disease (AD). This study aimed to explore alterations in the functional connectivity (FC) of NAc subregions in AD patients and to explore their associations with neuropsychological profiles.

METHODS

Total 45 AD patients and 41 healthy controls (HCs) were recruited for this study. Four subregions of the NAc were used as regions of interest for whole-brain FC analysis. Correlation analyses were conducted to explore the relationships between the changed FC of brain regions with significant differences and neuropsychological profiles.

RESULTS

Compared with HCs, decreased FC was observed between NAc subregions and regions of the orbitofrontal cortex (OFC), precuneus (PCUN), insula (INS), cerebellum 8, and putamen in AD patients (Gaussian random field [GRF] corrected, voxel-level p < 0.001, cluster-level p < 0.05). Furthermore, the FC between the left core and left PCUN was correlated with the score of the auditory verbal learning test immediate recall task in AD patients (r = 0.441, p = 0.003, Bonferroni corrected).

CONCLUSION

Disruptions in connectivity between the NAc subregions and important cognitive-related areas may be related to the cognitive deficits observed in AD patients, especially episodic memory function.