Association between polymorphism of MMP-1 promoter and the susceptibility to anterior disc displacement and temporomandibular joint osteoarthritis.

OBJECTIVE

To investigate the correlation of the polymorphism of MMP-1 promoter (-1607 1G/2G) with the susceptibility to anterior disc displacement (ADD) and temporomandibular joint osteoarthritis (TMJ OA).

METHODS

A total of 185 healthy individuals (group A), 141 unilateral ADDWR patients (group B), and 321 unilateral ADDWOR patients (group C) were included in the investigation. Group C included 115 patients without TMJ OA (named group C-1) and 206 with TMJ OA (named group C-2). The genotyping of this single nucleotide polymorphism was evaluated by high resolution melting assay. Pairwise comparison between the distributions of genotypes and alleles in these groups was conducted with a multivariate logistic regression model adjusted on the basis of possible covariates.

RESULTS

A significant difference in the 2G2G genotype frequency was found among the different groups on the basis of three sets of comparisons (P(C-A)<0.0005; P(C1-B)=0.049; P(C2-B)=0.018). The susceptibility of 2G2G genotype carriers to ADDWOR with or without TMJ OA was considerably higher than that of other genotypes carriers (OR(C-A)=2.455; OR(C1-B)=1.849; OR(C2-B)=1.912). A significant difference in 1G2G genotype frequency was also observed on the basis of two sets of comparisons (P(C-A)<0.0005; P(C2-B)=0.041). The susceptibility of 1G2G genotype carriers to ADDWOR with or without TMJ OA was also considerably higher than that of other genotype carriers (OR(C-A)=2.641; OR(C2-B)=1.896).

CONCLUSION

The -1607 1G/2G polymorphism of MMP-1 promoter may be related to the susceptibility to ADDWOR with or without TMJ OA.