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Войти в исследования ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans.
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Boekstegers Felix, Marcelain Katherine, Barahona Ponce Carol, Baez Benavides Pablo F, Müller Bettina, de Toro Gonzalo, Retamales Javier, Barajas Olga, Ahumada Monica, Morales Erik, Rojas Armando, Sanhueza Verónica, Loader Denisse, Rivera María Teresa, Gutiérrez Lorena, Bernal Giuliano, Ortega Alejandro, Montalvo Domingo, Portiño Sergio, Bertrán Maria Enriqueta, Gabler Fernando, Spencer Loreto, Olloquequi Jordi, González Silos Rosa, Fischer Christine, Scherer Dominique, Jenab Mazda, Aleksandrova Krasimira, Katzke Verena, Weiderpass Elisabete, Moradi Tahereh, Fischer Krista, Bossers Willem, Brenner Hermann, Hveem Kristian, Eklund Niina, Völker Uwe, Waldenberger Melanie, Fuentes Guajardo Macarena, Gonzalez-Jose Rolando, Bedoya Gabriel, Bortolini Maria C, Canizales Samuel, Gallo Carla, Ruiz Linares Andres, Rothhammer Francisco, Lorenzo Bermejo Justo
Аннотация
METHODS: This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication.
RESULTS: Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low.
CONCLUSION: Taking full advantage of genetic and ethnic differences in GBC risk may improve the efficiency of current prevention programs.