Journal of cutaneous medicine and surgery · 2013
Treatment of mycosis fungoides with bexarotene results in remission of diffuse plane xanthomas.
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Gregoriou Stamatis, Rigopoulos Dimitris, Stamou Christos, Nikolaou Vasiliki, Kontochristopoulos George
Аннотация
BACKGROUND: Cutaneous xanthomas develop as a result of intracellular and dermal deposition of lipids in either hyper- or normolipidemic patients. Plane xanthomas may signal the presence of an underlying monoclonal gammopathy, chronic myelomonocytic leukemia, or cutaneous T-cell lymphoma. Investigators have suggested that xanthomatized T cells may result in induction of plane xanthomas.
METHODS: We report the case of a patient with mycosis fungoides (MF) and plane xanthomas who was treated with bexarotene for his MF.
RESULTS: Significant improvement in the clinical signs of MF was observed within 3 months. We also observed a substantial regression of the xanthomas after 5 months of treatment. Complete clinical remission of both the MF and xanthomas was obtained after 6 months. The patient was still free of xanthomas after 3 years of follow-up.
CONCLUSION: Bexarotene led to the clearing of the cutaneous lesions of cutaneous T-cell lymphoma and plane xanthomas. This may be due to an effect of bexarotene on the aberrant T cells that may cause xanthomatization.
METHODS: We report the case of a patient with mycosis fungoides (MF) and plane xanthomas who was treated with bexarotene for his MF.
RESULTS: Significant improvement in the clinical signs of MF was observed within 3 months. We also observed a substantial regression of the xanthomas after 5 months of treatment. Complete clinical remission of both the MF and xanthomas was obtained after 6 months. The patient was still free of xanthomas after 3 years of follow-up.
CONCLUSION: Bexarotene led to the clearing of the cutaneous lesions of cutaneous T-cell lymphoma and plane xanthomas. This may be due to an effect of bexarotene on the aberrant T cells that may cause xanthomatization.