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Войти в исследования Clinical and experimental rheumatology · 2014
CC chemokine receptor polymorphism CCR5Δ32 in Portuguese Behçet's disease patients.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Bettencourt Andreia, Leal Bárbara, Carvalho Cláudia, Oliveira Rita, Martins Silva Ana, Vaz Patto José, Bastos Marina, Costa Luciana, Costa Paulo P, Vasconcelos Carlos, Correia João, Silva Berta M
Аннотация
OBJECTIVES: To investigate whether CCR5 deletion is associated with susceptibility to Behçet's disease (BD) in a Portuguese population.
METHODS: A total of 122 BD patients and 227 ethnically-matched controls were studied. Genotyping of the CCR5Δ32 polymorphisms was performed using polymerase chain reaction product sizing.
RESULTS: No significant differences were observed in the allelic frequencies of CCR532 between patients and controls (OR=0.820; p=0.512). Stratification for gender and for the presence of HLA-B*51 did not reveal any significant differences.
CONCLUSIONS: These results indicate that CCR5Δ32 is unlikely to contribute to susceptibility to BD in Portuguese patients. This may be explained by the known functional redundancy of this signalling system.
METHODS: A total of 122 BD patients and 227 ethnically-matched controls were studied. Genotyping of the CCR5Δ32 polymorphisms was performed using polymerase chain reaction product sizing.
RESULTS: No significant differences were observed in the allelic frequencies of CCR532 between patients and controls (OR=0.820; p=0.512). Stratification for gender and for the presence of HLA-B*51 did not reveal any significant differences.
CONCLUSIONS: These results indicate that CCR5Δ32 is unlikely to contribute to susceptibility to BD in Portuguese patients. This may be explained by the known functional redundancy of this signalling system.