Molecular diagnosis & therapy · 2014
Association of Rho-kinase 1 (ROCK1) gene polymorphisms with Behçet's disease.
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Oguz Elif, Demiryürek Abdullah Tuncay, Pehlivan Yavuz, Kisacik Bünyamin, Ozkara Esma, Oztuzcu Serdar, Alasehirli Belgin, Onat Ahmet Mesut
Аннотация
BACKGROUND AND OBJECTIVE: Behçet's disease (BD) is a chronic inflammatory vasculitis presenting with flares and silent periods usually between 15 and 40 years of age. The aim of this study was to evaluate the possible association between Rho-kinase 1 (ROCK1) gene polymorphisms and patients with BD in a Turkish population.
METHODS: A total of 192 BD patients and 255 healthy controls of similar age and sex were enrolled in this study. Polymorphisms were analyzed in genomic DNA using a BioMark HD dynamic array system.
RESULTS: In the presence of CC genotype for rs73963110, CT genotype for rs111874856 (Val355Ile), and TC genotype for rs112130712 (Lys1054Arg) polymorphisms, the risk of BD increased 12.13-, 15.05-, and 16.28-fold, respectively (p < 0.0001). There was a lower frequency of the GA genotype of the rs112108028 (Pro1164Leu) polymorphisms in BD (10.3 %) compared with controls (39.7 %; p < 0.0001). Marked associations between these polymorphisms and the manifestations of BD were recorded.
CONCLUSION: This is the first study to show that ROCK1 gene polymorphisms may have a significant impact on susceptibility to BD.
METHODS: A total of 192 BD patients and 255 healthy controls of similar age and sex were enrolled in this study. Polymorphisms were analyzed in genomic DNA using a BioMark HD dynamic array system.
RESULTS: In the presence of CC genotype for rs73963110, CT genotype for rs111874856 (Val355Ile), and TC genotype for rs112130712 (Lys1054Arg) polymorphisms, the risk of BD increased 12.13-, 15.05-, and 16.28-fold, respectively (p < 0.0001). There was a lower frequency of the GA genotype of the rs112108028 (Pro1164Leu) polymorphisms in BD (10.3 %) compared with controls (39.7 %; p < 0.0001). Marked associations between these polymorphisms and the manifestations of BD were recorded.
CONCLUSION: This is the first study to show that ROCK1 gene polymorphisms may have a significant impact on susceptibility to BD.