Facial plastic surgery & aesthetic medicine · 2026
Biochemical, Mechanical, and Warping Behavior of Fresh Frozen Costal Cartilage Allograft.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Fincher Garner C, Warren James D, Tayara Alia, Myatt Glenn D, Mechatto Abigail A, Iriarte Oporto Zelma, Patel Kush, Ansari Md Abu Yusuf, Spankovich Christopher, Williamson Randall S, Janorkar Amol, Jordan James R, Lee Jason H
Аннотация
BACKGROUND: Fresh frozen costal cartilage allografts are used in rhinoplasty, but their biomechanical and biochemical properties remain under-characterized.
OBJECTIVE: To determine whether cut orientation, harvest location, or irradiation status influences the biochemical, mechanical, and warping properties of a commercial fresh frozen costal cartilage allograft.
METHODS: Biochemical assays, three-point bending, and warping assessments were performed. Mixed-effects and linear regression models assessed associations with orientation, harvest location, and irradiation status. Intraclass correlation coefficients quantified donor-level variability.
RESULTS: Twenty-one specimens from 9 donors (mean age 43.1 years, 78% male, 44% irradiated) yielded 66 biochemical assays, 16 bending tests, and 143 warping observations. Collagen, sulfated glycosaminoglycan (sGAG), and collagen-to-sGAG ratio did not differ between cortical and medullary cartilage (p ≥ 0.55). DNA was lower in medullary samples (p = 0.02; ICC = 0.73). Elastic and flexural moduli did not differ by harvest location or irradiation status (p > 0.35). Median 60-min warping angle was 8.15° (IQR 5.76-11.26°). Median plateau time was 37.2 min, with 94% stabilizing within 45 min. The 15-minute warping angle was the strongest predictor of final graft geometry (coefficient 0.917, p < 0.001).
CONCLUSION: In this study, donor-level variation tended to exceed the effects of cut orientation, harvest location, or irradiation status.
OBJECTIVE: To determine whether cut orientation, harvest location, or irradiation status influences the biochemical, mechanical, and warping properties of a commercial fresh frozen costal cartilage allograft.
METHODS: Biochemical assays, three-point bending, and warping assessments were performed. Mixed-effects and linear regression models assessed associations with orientation, harvest location, and irradiation status. Intraclass correlation coefficients quantified donor-level variability.
RESULTS: Twenty-one specimens from 9 donors (mean age 43.1 years, 78% male, 44% irradiated) yielded 66 biochemical assays, 16 bending tests, and 143 warping observations. Collagen, sulfated glycosaminoglycan (sGAG), and collagen-to-sGAG ratio did not differ between cortical and medullary cartilage (p ≥ 0.55). DNA was lower in medullary samples (p = 0.02; ICC = 0.73). Elastic and flexural moduli did not differ by harvest location or irradiation status (p > 0.35). Median 60-min warping angle was 8.15° (IQR 5.76-11.26°). Median plateau time was 37.2 min, with 94% stabilizing within 45 min. The 15-minute warping angle was the strongest predictor of final graft geometry (coefficient 0.917, p < 0.001).
CONCLUSION: In this study, donor-level variation tended to exceed the effects of cut orientation, harvest location, or irradiation status.